Optimize Your Buffer Prep with White Mountain Process

Proper mixing is critical in producing buffer solution. First, the salt form needs to be completely dissolved and disassociated for all of its ions to be available to the equilibrium system. Next, the weak acid or base needs to be homogeneous in the solution for the proper equilibrium to be achieved. The pH usually needs to be adjusted to the final system’s pH level to be effective so good mixing is important during this step to ensure the correct additions are made for the final preparation.

Buffer Preparation, or “buffer prep” is a very common application in biopharma. Portable mixtanks or larger scale blending vessels are used to make up a buffer solution used in downstream feed for bioreactors.

Potential WMProcess mixers that could be used:

• SANITARY TOP ENTRY MIXER – for open top tank a C Clamp Mount mixer is typical, or for closed sealed vessels a TC mount agitator is common – mixers can be used on sanitary stainless vessels or FDA/USP VI poly tanks
• HIGH SHEAR MIXER– for rapid dispersion and dissolving on salts, powders, and pellets
• BOTTOM ENTRY MAGMIXER – Low shear gear drive mixers, medium shear direct drive bottom mag mixers, and high shear mag drive agitators can be used for buffer make up. WMProcess can accommodate mag drive mixers on either stainless tanks or poly vessels.