Bending Moment is the Hydraulic Force (FH) acting on a shaft at a length away from the bearings perpendicular to the axis of rotation. Bending Moment causes the shaft to bend away from the central rotational axis and is critical to determine the shaft material, diameter and bearing design. Excessive bending moments or weak materials of construction can lead to catastrophic failures. The bending moment for each impeller is calculated using the applied Horsepower (HP) and impeller distance from the load bearings. The speed of the mixer and diameter of the impeller is also taken into account as well as whether or not the impeller is submerged or at the liquid surface (important for filling and emptying). After the bending moment is established, the amount of shaft deflection can be estimated using the shaft diameter and the material’s Modulus of Elasticity.
Add some innovation to your next batch with single use mixers and disposable mixers from White Mountain Process – and save valuable processing and validation time!
Our single use mixers offer a better way to cut mixing time and significantly reduce cross contamination for aseptic processes such as mixing food, beverage, cosmetics, biopharma and other mixing processes in cGMP environments.
Eliminate cross contamination and speed up turnaround time with single use mixers from the specialists at White Mountain Process. Disposable mixers offer major advantages, such as increasing production while reducing labor costs, as well as other benefits like:
- Cut cleaning time
- No CIP or SIP issues
- Reduce validation costs
- Less wastewater
- Less product waste
- Great for sensitive or sterile materials
- No impellers
Mix powder, liquids and liquid solutions with mixing bags engineered with film flaps and slots designed to thoroughly mix media throughout the mix bag.
Available in sizes ranging 30 to 5,000 liters, our single use mixer provides truly scalable mixing action and can combine process operations. Your mixing lab will appreciate faster start-up times and shorter cycle times.
Ideal in environments where portability is key, single use mixing systems offer scalable, fast and efficient mixing in one economic package.
While disposable, single use mixers are manufactured to meet cGMP criteria, with the primary expectation of creating a helpful product for the bioprocessing industry.
How Single Use Mixers Work
While single mixers vary depending on the application and size, they generally consist of an in-bag impeller which creates mixing action inside a hermetically sealed bag. No dynamic seals are required and the shaft does not go inside the mixing bag. This system allows for easier mixing of multiple batches in bags – even if the bags are different sizes – with a single use mixer.
Single use mixing bags, while disposable, are designed for rigorous mixing, as well as the media’s exposure to the bag (generally using only a TK8 bioprocesses film where bag is in contact with media). Using a medical-grade poly resin, the bag is generally laminated to create a very strong, ADCF-compliant bag which meets medical-grade requirements.
Applications for Single Use Mixers
Why use a single use mixer for mixing biopharma, buffer and media prep? Mainly for economic and operational efficiency. Labs using single use mixers save valuable processing and validation time.
- Media prep
- Buffer prep
- Product mixing
- Drug formulation mixing
- pH / conductivity adjustment
- Difficult mixing applications
- Dense powers, high viscosities
- Applications requiring repeated, fast-mixing processes
Some industries that do not have cGMP requirements to meet may still benefit greatly from single use mixers, simply because of the fast set-up and clean up time.
Also known as sealed mixing vessel technology or disposable mixers, single use mixers are becoming increasingly popular in industries such as nanomaterial mixing, coating granules or pellets, incorporating liquids into powders and mixing dissimilar powders.
Additional Applications Include:
- Gases, liquids, powders, solids and pastes
- Adhesives, sealants and caulks
- Inks and pigments
- Advanced materials
- Electronic pastes and inks
Major Cost & Time-Savings Benefits
The benefits of single use mixers are clear – they eliminate the need for tank cleaning, significantly reduce cycle times and eliminates the risk of cross contamination. Additionally, single use or disposable mixers significantly reduce start-up costs.
Highly suited for buffer prep and media prop, in addition to cell harvest, buffer exchange and inactivation. Single use mixers also keep lab technicians safer by minimizing exposure to inhalable powders. Other benefits include:
- Very easy to set-up and use
- Easy to transport
- Can increase production capability, especially in multi-product mixing labs
- Decreases or eliminates risk of cross-contamination
- Reduces downtime for cleaning validation
- Good Engineering Practice (GEP) compliant designs available for super-efficient mixing performance
Single use mixers can be customized with connectors, filters and tubing, to suit your process or lab environment.
Reduce the risk of contamination while improving your costs! Contact White Mountain Process for a consultation to discuss your process and mixing needs.
What may have been high-end equipment 20 years ago may cause your company serious problems now. While it may function reliably, if your drug manufacturing process isn’t cGMP compliant, you risk regulatory action from the FDA. Ensure your system meets FDA standards now, by contacting a White Mountain Process specialist to review your current mixing system.
Current Good Manufacturing Practices (cGMP) are necessary guidelines for drug manufacturing. While people assume all manufacturers adhere to these practices, remarkably some manufacturers have not upgraded equipment to current processes and standards.
When it comes to drug products, cGMPs provide a solid foundation for good product quality. Our trained specialists can help you determine current weaknesses in your production and mixing equipment so you can remedy any potential problems quickly. We offer design assistance, necessary documentation, and can help you create a cGMP compliant manufacturing process in your lab to certify product purity.
With the proper systems in place, your manufacturing can guarantee product quality, thanks to strict quality management systems and solid operating procedures. We can help you take your drug manufacturing to the next level by assisting you with critical upgrades in equipment and record keeping strategies. Your company will enjoy the two-fold benefits of smarter production processes – including greater efficiency and a better end product.
Are contamination issues, product mix-ups, waste and errors a problem for your drug mixing production? Be sure your products meet quality standards with the latest in high performance equipment. Introduce the latest mixtank equipment designed for CIP and SIP processes, mixing designed for portability and improve your overall mixing processes and results.
Is your goal to apply more internal stringent requirements?
If quality is your company’s number one goal, let us introduce you to modernized systems which will greatly exceed minimum FDA standards. We build quality into your mixtank, taking into account your specific mixing procedures so you can develop reproducible processes and measurable results to guarantee the safety and effectiveness of the products you manufacture.
Have the assurance that your systems will pass critical inspections by following cGMP standards and regulations with robust mixing systems from White Mountain Process. Contact us to help with:
- Solid to liquid applications requiring aggressive mixing
- Efficient mixing for a wide variety of applications
- Single-use mixing systems, single-use mixing bags
- Buffer and media prep
- Design assistance for setting up your cGMP certified cleanroom
- CIP and SIP mixtank systems
- Individual accessories, or complete, turn-key mixtank solutions
- High shear mixers and granulators
- Bulk containers, wash stations and blenders
Since the pharmacological and pathophysiological implications for cGMP drug production are many, White Mountain Process stays abreast of all changes and modifications, as well as the demands in the industry by major players in the drug manufacturing industry. Put our experience to work for you with engineering assistance, processing tips and valuable advice from the professionals who deal with high-end mixing every day.
With properly designed mixing systems tailored to your process and application, your products can make a difference in the life of your end customer, as well as your bottom line. The professionals at White Mountain Process can help you improve your mixing processes, from start to finish, including reporting and cleaning routines. It’s our goal to help your company provide advanced mixing processes and thereby helping you to assure your pharma or biotech mixing department is providing consistent quality to customers, every time.
Call us today to help your company stay ahead of the curve by developing effective and safe batches consistently.